Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy.
Identifieur interne : 000104 ( Main/Exploration ); précédent : 000103; suivant : 000105Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy.
Auteurs : Jin-Cherng Lien [Taïwan] ; Meng-Wei Lin [Taïwan] ; Shu-Jen Chang [Taïwan] ; Kuang-Chi Lai [Taïwan] ; An-Cheng Huang [Taïwan] ; Fu-Shun Yu [Taïwan] ; Jing-Gung Chung [Taïwan]Source :
- Environmental toxicology [ 1522-7278 ] ; 2017.
Descripteurs français
- KwdFr :
- Acétylcystéine (pharmacologie), Altération de l'ADN (effets des médicaments et des substances chimiques), Apoptose (effets des médicaments et des substances chimiques), Autophagie (effets des médicaments et des substances chimiques), Benzylisoquinoléines (toxicité), Bécline-1 (métabolisme), Calcium (métabolisme), Caspases (métabolisme), Espèces réactives de l'oxygène (métabolisme), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Microscopie électronique (MeSH), Potentiel de membrane mitochondriale (effets des médicaments et des substances chimiques), Protéines associées aux microtubules (métabolisme), Protéines régulatrices de l'apoptose (métabolisme), Tumeurs de la bouche (anatomopathologie), Tumeurs de la bouche (métabolisme).
- MESH :
- anatomopathologie : Tumeurs de la bouche.
- effets des médicaments et des substances chimiques : Altération de l'ADN, Apoptose, Autophagie, Potentiel de membrane mitochondriale.
- métabolisme : Bécline-1, Calcium, Caspases, Espèces réactives de l'oxygène, Protéines associées aux microtubules, Protéines régulatrices de l'apoptose, Tumeurs de la bouche.
- pharmacologie : Acétylcystéine.
- toxicité : Benzylisoquinoléines.
- Humains, Lignée cellulaire tumorale, Microscopie électronique.
English descriptors
- KwdEn :
- Acetylcysteine (pharmacology), Apoptosis (drug effects), Apoptosis Regulatory Proteins (metabolism), Autophagy (drug effects), Beclin-1 (metabolism), Benzylisoquinolines (toxicity), Calcium (metabolism), Caspases (metabolism), Cell Line, Tumor (MeSH), DNA Damage (drug effects), Humans (MeSH), Membrane Potential, Mitochondrial (drug effects), Microscopy, Electron (MeSH), Microtubule-Associated Proteins (metabolism), Mouth Neoplasms (metabolism), Mouth Neoplasms (pathology), Reactive Oxygen Species (metabolism).
- MESH :
- chemical , metabolism : Apoptosis Regulatory Proteins, Beclin-1, Calcium, Caspases, Microtubule-Associated Proteins, Reactive Oxygen Species.
- chemical , pharmacology : Acetylcysteine.
- drug effects : Apoptosis, Autophagy, DNA Damage, Membrane Potential, Mitochondrial.
- metabolism : Mouth Neoplasms.
- pathology : Mouth Neoplasms.
- chemical , toxicity : Benzylisoquinolines.
- Cell Line, Tumor, Humans, Microscopy, Electron.
Abstract
Tetrandrine, a bisbenzylisoquinoline alkaloid, is extracted from the root of the Chinese herb Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer cell types. In this study, the effects of tetrandrine on human oral cancer CAL 27 cells were examined. Results indicated that tetrandrine induced cytotoxic activity in CAL 27 cells. Effects were due to cell death by the induction of apoptosis and accompany with autophagy and these effects were concentration- and time-dependent manners. Tetrandrine induced apoptosis was accompanied by alterations in cell morphology, chromatin fragmentation, and caspase activation in CAL 27 cells. Tetrandrine treatment also induced intracellular accumulation of reactive oxygen species (ROS). The generation of ROS may play an important role in tetrandrine-induced apoptosis. Tetrandrine triggered LC3B expression and induced autophagy in CAL 27 cells. Tetrandrine induced apoptosis and autophagy were significantly attenuated by N-acetylcysteine pretreatment that supports the involvement of ROS production. Tetrandrine induced cell death may act through caspase-dependent apoptosis with Beclin-1-induced autophagy in human oral cancer cells. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 329-343, 2017.
DOI: 10.1002/tox.22238
PubMed: 26822499
Affiliations:
Links toward previous steps (curation, corpus...)
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wicri:level="1"><nlm:affiliation>Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei, 231, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei, 231</wicri:regionArea><wicri:noRegion>231</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Shu Jen" sort="Chang, Shu Jen" uniqKey="Chang S" first="Shu-Jen" last="Chang">Shu-Jen Chang</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, China Medical University, Taichung, 404, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Pharmacy, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation></author><author><name sortKey="Lai, Kuang Chi" sort="Lai, Kuang Chi" uniqKey="Lai K" first="Kuang-Chi" last="Lai">Kuang-Chi Lai</name><affiliation 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xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biological Science and Technology, China Medical University, Taichung, 404</wicri:regionArea><wicri:noRegion>404</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Asia University, Taichung, 413, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Biotechnology, Asia University, Taichung, 413</wicri:regionArea><wicri:noRegion>413</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental toxicology</title><idno type="eISSN">1522-7278</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcysteine (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Apoptosis Regulatory Proteins (metabolism)</term><term>Autophagy (drug effects)</term><term>Beclin-1 (metabolism)</term><term>Benzylisoquinolines (toxicity)</term><term>Calcium (metabolism)</term><term>Caspases (metabolism)</term><term>Cell Line, Tumor (MeSH)</term><term>DNA Damage (drug effects)</term><term>Humans (MeSH)</term><term>Membrane Potential, Mitochondrial (drug effects)</term><term>Microscopy, Electron (MeSH)</term><term>Microtubule-Associated Proteins (metabolism)</term><term>Mouth Neoplasms (metabolism)</term><term>Mouth Neoplasms (pathology)</term><term>Reactive Oxygen Species (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcystéine (pharmacologie)</term><term>Altération de l'ADN (effets des médicaments et des substances chimiques)</term><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Autophagie (effets des médicaments et des substances chimiques)</term><term>Benzylisoquinoléines (toxicité)</term><term>Bécline-1 (métabolisme)</term><term>Calcium (métabolisme)</term><term>Caspases (métabolisme)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Humains (MeSH)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Microscopie électronique (MeSH)</term><term>Potentiel de membrane mitochondriale (effets des médicaments et des substances chimiques)</term><term>Protéines associées aux microtubules (métabolisme)</term><term>Protéines régulatrices de l'apoptose (métabolisme)</term><term>Tumeurs de la bouche (anatomopathologie)</term><term>Tumeurs de la bouche (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Apoptosis Regulatory Proteins</term><term>Beclin-1</term><term>Calcium</term><term>Caspases</term><term>Microtubule-Associated Proteins</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcysteine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Autophagy</term><term>DNA Damage</term><term>Membrane Potential, Mitochondrial</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Altération de l'ADN</term><term>Apoptose</term><term>Autophagie</term><term>Potentiel de membrane mitochondriale</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bécline-1</term><term>Calcium</term><term>Caspases</term><term>Espèces réactives de l'oxygène</term><term>Protéines associées aux microtubules</term><term>Protéines régulatrices de l'apoptose</term><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétylcystéine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Benzylisoquinolines</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Benzylisoquinoléines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Humans</term><term>Microscopy, Electron</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Microscopie électronique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tetrandrine, a bisbenzylisoquinoline alkaloid, is extracted from the root of the Chinese herb Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer cell types. In this study, the effects of tetrandrine on human oral cancer CAL 27 cells were examined. Results indicated that tetrandrine induced cytotoxic activity in CAL 27 cells. Effects were due to cell death by the induction of apoptosis and accompany with autophagy and these effects were concentration- and time-dependent manners. Tetrandrine induced apoptosis was accompanied by alterations in cell morphology, chromatin fragmentation, and caspase activation in CAL 27 cells. Tetrandrine treatment also induced intracellular accumulation of reactive oxygen species (ROS). The generation of ROS may play an important role in tetrandrine-induced apoptosis. Tetrandrine triggered LC3B expression and induced autophagy in CAL 27 cells. Tetrandrine induced apoptosis and autophagy were significantly attenuated by N-acetylcysteine pretreatment that supports the involvement of ROS production. Tetrandrine induced cell death may act through caspase-dependent apoptosis with Beclin-1-induced autophagy in human oral cancer cells. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 329-343, 2017.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">26822499</PMID><DateCompleted><Year>2017</Year><Month>03</Month><Day>08</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-7278</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Environmental toxicology</Title><ISOAbbreviation>Environ Toxicol</ISOAbbreviation></Journal><ArticleTitle>Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy.</ArticleTitle><Pagination><MedlinePgn>329-343</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/tox.22238</ELocationID><Abstract><AbstractText>Tetrandrine, a bisbenzylisoquinoline alkaloid, is extracted from the root of the Chinese herb Radix Stephania tetrandra S Moore. This compound has antitumor activity in different cancer cell types. In this study, the effects of tetrandrine on human oral cancer CAL 27 cells were examined. Results indicated that tetrandrine induced cytotoxic activity in CAL 27 cells. Effects were due to cell death by the induction of apoptosis and accompany with autophagy and these effects were concentration- and time-dependent manners. Tetrandrine induced apoptosis was accompanied by alterations in cell morphology, chromatin fragmentation, and caspase activation in CAL 27 cells. Tetrandrine treatment also induced intracellular accumulation of reactive oxygen species (ROS). The generation of ROS may play an important role in tetrandrine-induced apoptosis. Tetrandrine triggered LC3B expression and induced autophagy in CAL 27 cells. Tetrandrine induced apoptosis and autophagy were significantly attenuated by N-acetylcysteine pretreatment that supports the involvement of ROS production. Tetrandrine induced cell death may act through caspase-dependent apoptosis with Beclin-1-induced autophagy in human oral cancer cells. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 329-343, 2017.</AbstractText><CopyrightInformation>© 2016 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lien</LastName><ForeName>Jin-Cherng</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, 404, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Meng-Wei</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, New Taipei, 231, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Shu-Jen</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>School of Pharmacy, China Medical University, Taichung, 404, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Kuang-Chi</ForeName><Initials>KC</Initials><AffiliationInfo><Affiliation>Department of Surgery, China Medical University Beigang Hospital, Yunlin, 651, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University Hospital, Taichung, 404, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>An-Cheng</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Nursing, St. Mary's Medicine Nursing and Management College, Yilan, 266, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Fu-Shun</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Department of Dentist, China Medical University, Taichung, 404, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Jing-Gung</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of Biological Science and Technology, China Medical University, Taichung, 404, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biotechnology, Asia University, Taichung, 413, Taiwan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Environ Toxicol</MedlineTA><NlmUniqueID>100885357</NlmUniqueID><ISSNLinking>1520-4081</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051017">Apoptosis Regulatory Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491997">BECN1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071186">Beclin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044182">Benzylisoquinolines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502070">MAP1LC3B protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008869">Microtubule-Associated Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>29EX23D5AJ</RegistryNumber><NameOfSubstance UI="C009438">tetrandrine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D020169">Caspases</NameOfSubstance></Chemical><Chemical><RegistryNumber>SY7Q814VUP</RegistryNumber><NameOfSubstance UI="D002118">Calcium</NameOfSubstance></Chemical><Chemical><RegistryNumber>WYQ7N0BPYC</RegistryNumber><NameOfSubstance UI="D000111">Acetylcysteine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000111" MajorTopicYN="N">Acetylcysteine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051017" MajorTopicYN="N">Apoptosis Regulatory Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071186" MajorTopicYN="N">Beclin-1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044182" MajorTopicYN="N">Benzylisoquinolines</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002118" MajorTopicYN="N">Calcium</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020169" MajorTopicYN="N">Caspases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004249" MajorTopicYN="N">DNA Damage</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053078" MajorTopicYN="N">Membrane Potential, Mitochondrial</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008869" MajorTopicYN="N">Microtubule-Associated Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009062" MajorTopicYN="N">Mouth Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">CAL 27 cell line</Keyword><Keyword MajorTopicYN="Y">apoptosis</Keyword><Keyword MajorTopicYN="Y">autophagy</Keyword><Keyword MajorTopicYN="Y">oral cancer</Keyword><Keyword MajorTopicYN="Y">tetrandrine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>01</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>3</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26822499</ArticleId><ArticleId IdType="doi">10.1002/tox.22238</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lien, Jin Cherng" sort="Lien, Jin Cherng" uniqKey="Lien J" first="Jin-Cherng" last="Lien">Jin-Cherng Lien</name></noRegion><name sortKey="Chang, Shu Jen" sort="Chang, Shu Jen" uniqKey="Chang S" first="Shu-Jen" last="Chang">Shu-Jen Chang</name><name sortKey="Chung, Jing Gung" sort="Chung, Jing Gung" uniqKey="Chung J" first="Jing-Gung" last="Chung">Jing-Gung Chung</name><name sortKey="Chung, Jing Gung" sort="Chung, Jing Gung" uniqKey="Chung J" first="Jing-Gung" last="Chung">Jing-Gung Chung</name><name sortKey="Huang, An Cheng" sort="Huang, An Cheng" uniqKey="Huang A" first="An-Cheng" last="Huang">An-Cheng Huang</name><name sortKey="Lai, Kuang Chi" sort="Lai, Kuang Chi" uniqKey="Lai K" first="Kuang-Chi" last="Lai">Kuang-Chi Lai</name><name sortKey="Lai, Kuang Chi" sort="Lai, Kuang Chi" uniqKey="Lai K" first="Kuang-Chi" last="Lai">Kuang-Chi Lai</name><name sortKey="Lin, Meng Wei" sort="Lin, Meng Wei" uniqKey="Lin M" first="Meng-Wei" last="Lin">Meng-Wei Lin</name><name sortKey="Yu, Fu Shun" sort="Yu, Fu Shun" uniqKey="Yu F" first="Fu-Shun" last="Yu">Fu-Shun Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy.
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